When skin starts to look dull, crepey or tired, whether that is across the face, under the eyes, on the neck or on the hands, the issue is often skin quality rather than lost volume.
Polynucleotides work on the condition and resilience of the skin itself. The areas where ageing tends to show first.
At Skinfinity, polynucleotide treatment is led by doctors at our CQC-registered clinic within LivingCare Private Hospital in Thorpe Park, Leeds. The clinic is convenient for patients travelling from Cross Gates, Garforth and across Leeds.
Polynucleotides can be used for overall skin rejuvenation, although the under-eye area is one of the most common reasons patients ask about treatment.
Polynucleotides are purified chains of DNA fragments. At Skinfinity, we use Plinest by Mastelli, which is well established across Europe.
Once injected into the skin, polynucleotides act as a biostimulator. They support the skin’s own repair processes, hydration and collagen activity over a course of sessions.
You may also have seen the treatment described as “salmon sperm injections” or the “salmon sperm facial”. These names refer to the origin of the polynucleotides. The treatment uses a purified product designed to improve skin quality rather than add the volume you would expect from a filler.
Read our full guide - The salmon sperm facial explained.
Polynucleotides do not fill or reshape the face. They encourage the skin to do more of what younger skin does naturally.
They support fibroblasts, the cells responsible for producing collagen and elastin, and help the skin hold hydration and repair itself. Over a course of treatment, the skin can look smoother, more even and better hydrated. It may also feel firmer.
The change is gradual because the treatment works with your own biology. Individual results vary.
Polynucleotides are used across areas where the skin tends to thin, become crepey or lose firmness:
Polynucleotides improve the condition of the skin rather than adding volume. This can suit patients who want a natural, refined result rather than an obvious change.
Your doctor will assess your concerns and advise which areas are suitable during your consultation.
The under-eye area is one of the most common reasons patients ask about polynucleotides.
The skin here is thin and delicate. Because polynucleotides target skin quality, treatment can help improve hydration and texture so the area may look fresher and less tired over a course of sessions.
Results develop gradually. Subtle is the point.
Some patients will be better suited to a combined treatment plan or a different approach altogether. Your doctor will assess the cause of your concern and advise you honestly.
Read more in our blog: Polynucleotides under the eyes vs tear trough filler.
Filler and polynucleotides solve different problems.
Filler adds volume to a specific area. Polynucleotides improve the quality and resilience of the skin itself.
If your concern is a hollow, such as a tear trough, filler may be appropriate. If the problem is skin quality, polynucleotides or another injectable skin treatment such as Sunekos or Profhilo may make more sense.
Sometimes the right answer is a carefully planned combination.
Because Skinfinity is doctor-led, we recommend what genuinely suits your face. Not a single signature treatment for everyone.
Results typically last around six to nine months. This varies depending on your age, skin condition, lifestyle and the area treated.
Results build over the course of treatment and can be maintained with periodic top-up sessions.
At Skinfinity, polynucleotide treatment is led by doctors and carried out in a CQC-registered clinic.
All injectable treatments carry risks. Your doctor will explain these fully before you decide whether to proceed.
Polynucleotide treatment starts from £300 for a single under-eye treatment and £350 for the face. Course packages are also available.
Your total cost will depend on the area treated and the number of sessions recommended. We will explain the full price of your plan at your consultation. No surprises later.
Start with a consultation.
A doctor will assess your skin, listen to what you want to improve and explain whether polynucleotides are suitable for you.
Skinfinity is based within LivingCare Private Hospital, 4600 Park Approach, Thorpe Park, Leeds LS15 8GB. The clinic is convenient for patients travelling from Cross Gates, Garforth and across Leeds.
Treatment starts from £300 for a single under-eye session and £350 for the face. Course packages are also available. Your full treatment cost will be confirmed at your consultation.
More serious risks are rare but can include localised infection, small lumps under the skin, or an allergic reaction. To minimise these risks we carry out a thorough consultation beforehand, use only high-quality products, and provide clear aftercare instructions.
Immediately after a polynucleotide treatment, you may notice some mild and temporary side effects, which are completely normal and typically settle within a few hours to a couple of days.
You can expect:
These effects are usually short-lived and should not interfere with your daily activities. It’s advised to avoid touching the area, wearing makeup for at least 6 hours, and to steer clear of heat (like saunas, steam rooms, or hot baths), intense exercise, and alcohol for 24–48 hours. Your practitioner will provide personalised aftercare guidance based on your treatment area.
The results of polynucleotide treatments typically last around 6 to 9 months, depending on individual factors such as age, skin condition, lifestyle, and the area being treated.
For best results, a course of treatments is usually recommended—often 3 sessions spaced 2–4 weeks apart. After the initial course, maintenance treatments every 6 months help to prolong and enhance the benefits. Over time, with consistent treatment, many patients see continued improvements in skin texture, hydration, firmness, and overall skin quality.
Polynucleotide treatments are generally considered safe when carried out by a qualified medical professional. They use highly purified DNA fragments—often derived from salmon or trout—that are biocompatible and well-tolerated by the body. These treatments work by stimulating tissue regeneration, improving skin hydration, and encouraging collagen production. Because the polynucleotides are extensively purified and free from chemical cross-linking agents, the risk of allergic reactions or complications is low. Side effects are typically minimal, with some mild swelling, redness, or bruising at the injection sites, which usually settle within a few days.
At Skinfinity, polynucleotide treatment is led by doctors and carried out in a CQC-registered clinic. All injectable treatments carry risks. Your doctor will discuss these fully with you before you decide whether to proceed.
Treatment takes approximately 30-45 minutes depending on what areas are being teated
Improved skin texture, tone, quality, and reduced lines.
Local anesthesia cream for approx. 20 minutes.
Men and women looking to rejuvenate and improve skin.
Skin typically recovers within hours. A chance of slight swelling and bruising at the injection site.
Packages are available from £850